General
Preferred name
Diloxanide
Synonyms
P&D ID
PD016233
CAS
579-38-4
Tags
available
drug candidate
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Diloxanide is used alone as a primary agent in the treatment of asymptomatic (cyst passers) intestinal amebiasis caused by Entamoeba histolytica. Diloxanide may also be used concurrently, or sequentially, with other agents such as the nitroimidazoles (eg. metronidazole) in the treatment of invasive or extraintestinal forms of amebiasis.;
DESCRIPTION Diloxanide is a luminal amebicide used in the treatment of amebiasis which is an infection of the diegestive tract caused by amoebas of the entamoeba group. It is considered the choice for asymptomatic cyst carriers. It is a second line treatment after paromomycin when no symptoms are present in places where infections are not common. (BOC Sciences Bioactive Compounds)
Compound Sets
6
BOC Sciences Bioactive Compounds
diloxanide-cas-579-38-4-item-72132
ChEMBL Drugs
CHEMBL2103768
DrugBank
DB08792
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-119972
ReFrame library
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
233.0
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
2.16
TPSA
40.54
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Anti-infection
Target
Parasite
Solubility
Soluble in DMSO, not in water
Source data