General
Preferred name
CEFTAROLINE FOSAMIL
Synonyms
Ceftaroline fosamil (hydrate) ()
TAK-599 (hydrate) ()
PPI0903 (hydrate) ()
CEFTAROLINE FOSAMIL ACETATE ()
Teflaro ()
Ceftaroline fosamil anhydrous ()
TAK-599 ()
TAK 599 ()
Ceftarolina fosamilo ()
PPI-0903 ()
TAK599 ()
Ceftaroline Fosamil ()
Ceftaroline fosamil monoacetate monohydrate ()
Tak-599 monoacetate monohydrate ()
Ppi-0903 monoacetate monohydrate ()
Ceftaroine ()
Zinforo ()
P&D ID
PD016226
CAS
866021-48-9
402741-13-3
400827-55-6
229016-73-3
Tags
available
prodrug
drug
Approved by
FDA
First approval
2010
Drug Status
approved
investigational
Max Phase
4.0
Drug indication
infection
Bacterial pneumonia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS The time that unbound plasma concentration of ceftaroline exceeds the minimum inhibitory concentration (MIC) of the infecting organism has been shown to best correlate with efficacy in a neutropenic murine thigh infection model with S. aureus and S. pneumoniae.; ; No significant effect on QTc (corrected QT interval) interval was detected at peak plasma concentration or at any other time.
TOXICITY LD50/LC50:; Draize test, rabbit, eye: 100 mg/24H Moderate; Oral,; mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat:; LD50 = 980 mg/kg.
DESCRIPTION Ceftaroline fosamil is a fifth-generation cephalosporin prodrug which is hydrolysed to the active form, ceftaroline, in vivo. It has anti-MRSA activity . Ceftaroline was removed from the World Health Organization's List of Essential Medicines in 2019. (GtoPdb)
DESCRIPTION Ceftaroline fosamil hydrate is a potent cephalosporin antibiotic. Ceftaroline fosamil hydrateshows broad-spectrum activity against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Streptococcus pneumoniae, and common Gram-negative organisms. Ceftaroline fosamil hydrate has anti-infective activity, and can be used for the research of complicated skin and skin structure infections (cSSSIs) and community-acquired bacterial pneumonia (CABP)[1][2][3].
DESCRIPTION Ceftaroline fosamil is a cephalosporin antibacterial indicated for the treatment of adults with acute bacterial skin and soft tissue infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). (BOC Sciences Bioactive Compounds)
Compound Sets
9
BOC Sciences Bioactive Compounds
ceftaroline-fosamil-cas-229016-73-3-item-63435
ChEMBL Approved Drugs
CHEMBL501122
CHEMBL3544973
ChEMBL Drugs
CHEMBL501122
CHEMBL3544973
DrugBank
DB06590
DrugBank Approved Drugs
DB06590
DrugCentral
4169
DrugCentral Approved Drugs
4169
Guide to Pharmacology
10899
MedChem Express Bioactive Compound Library
HY-14737A
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
684.01
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
4
Rotatable Bonds
11
Ring Count
5
Aromatic Ring Count
3
cLogP
-0.11
TPSA
223.24
Fraction CSP3
0.27
Chiral centers
2.0
Largest ring
6.0
QED
0.07
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
Pathway
Anti-infection
Source data