General
Preferred name
PROTIRELIN
Synonyms
TRF Acetate ()
TRH Acetate ()
TSH-RF Acetate ()
Synthetic thyrotropin-releasing factor ()
Synthetic thyrotropin-releasing hormone ()
TRF ()
TSH-RF ()
pGlu-His-Pro-NH2 ()
{pGLU}HP-NH2 ()
pGlu-His-Pro-NH2 Acetate ()
Synthetic thyrotropin-releasing hormone Acetate ()
Thyroliberin Acetate ()
Lopremone Acetate ()
Protirelin Acetate(24305-27-9 free base) ()
Rifathyroin ()
Protirelin ()
Protirelin (Acetate) ()
Thyrotropin-releasing-hormone (acetate) ()
TRH (acetate) ()
Thyrotropin-releasing-hormone ()
TRH ()
[3H]TRH (human, mouse, rat) ()
Thyrotropin-releasing factor ()
Synthetic Trh ()
Thyrel Trh ()
5-oxo-pro-his-pro-nh2 ()
TRH-Cambridge ()
THYROTROPIN RELEASING HORMONE ()
NSC-760113 ()
Thypinone ()
Thyrotropin-Releasing Hormone ()
Protirelin tartrate ()
A-38579 ()
ABBOTT-38579 ()
Thyroliberin ()
Thyroid releasing hormone ()
Protirelin, synthetic ()
Relefact trh ()
Lopremone ()
P&D ID
PD016199
CAS
24305-27-9
11096-37-0
120876-23-5
Tags
natural product
drug
available
Approved by
FDA
First approval
1976
Drug Status
investigational
approved
withdrawn
Drug indication
Prothyrotropin
Central nervous system disease
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This structure matches the structure deposited with the INN record for protirelin, which is synthetic TRH. (GtoPdb)
Compound Sets
19
Cayman Chemical Bioactives
22917
ChEMBL Approved Drugs
CHEMBL1472
ChEMBL Drugs
CHEMBL1472
Drug Repurposing Hub
DrugBank
DB09421
DrugBank Approved Drugs
DB09421
DrugCentral
2316
DrugCentral Approved Drugs
2316
DrugMAP
DMGN5QD
DrugMAP Approved Drugs
DMGN5QD
Guide to Pharmacology
2139
3836
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1472
Mcule NIBR MoA Box Subset
MCULE-3913449637
MedChem Express Bioactive Compound Library
HY-P0002
HY-P0002A
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T6956L
Withdrawn 2.0
1381
ZINC Tool Compounds
ZINC000004096261
External IDs
56
Properties
(calculated by RDKit )
Molecular Weight
362.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
1
cLogP
-1.81
TPSA
150.28
Fraction CSP3
0.56
Chiral centers
3.0
Largest ring
5.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Vitamin D Related/Nuclear Receptor
Metabolic Enzyme/Protease
Target
thyroid hormone
TRHR
Thyroid hormone receptor
Endogenous Metabolite
Member status
virtual
MOA
Thyrotropin releasing hormone agonists
thyrotropin releasing hormone receptor agonist
Indication
thyroid function diagnostic
ATC
V04CJ02
Therapeutic Class
Neurology Agents
Source data