General
Preferred name
PERAMIVIR
Synonyms
BCX-1812 ()
BCX 1812 trihydrate ()
RWJ 270201 trihydrate ()
S-021812 ()
RWJ-270201 ()
Peramivir Trihydrate ()
PERAMIVIR ANHYDROUS ()
Peramivir (trihydrate) ()
Rapiacta ()
Peramivir hydrate ()
Rapivab ()
Alpivab ()
Peramivir trihydrate ()
P&D ID
PD016191
CAS
1041434-82-5
229614-56-6
330600-85-6
Tags
available
drug
Approved by
FDA
EMA
First approval
2014
Drug indication
Influenza virus infection
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Peramivir is an inhibitor of influenza neuraminidase, preventing new virus particles from leaving infected cells.
INDICATION Indicated for the treatment of acute uncomplicated influenza in patients 18 years and older who have been symptomatic for no more than two days.[label]
DESCRIPTION Peramivir Trihydrate is a trihydrate of the anti-infection agent peramivir (RWJ-270201,BCX-1812) which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
3
Compound Sets
19
AdooQ Bioactive Compound Library
A11124
BOC Sciences Bioactive Compounds
peramivir-trihydrate-cas-1041434-82-5-item-84-452647
Cayman Chemical Bioactives
23765
ChEMBL Approved Drugs
CHEMBL3989402
CHEMBL139367
ChEMBL Drugs
CHEMBL3989402
CHEMBL139367
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06614
DrugBank Approved Drugs
DB06614
DrugCentral
4823
DrugCentral Approved Drugs
4823
DrugMAP
DMNXY5K
DrugMAP Approved Drugs
DMNXY5K
EU-OPENSCREEN Bioactive Compound Library
EOS100843
MedChem Express Bioactive Compound Library
HY-17015
HY-17015A
NCATS Inxight Approved Drugs
9ZS94HQO3B
Pandemic Response Box
ReFrame library
TargetMol Bioactive Compound Library
T2522
External IDs
52
Properties
(calculated by RDKit )
Molecular Weight
328.21
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
6
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
0
cLogP
-0.14
TPSA
148.53
Fraction CSP3
0.8
Chiral centers
5.0
Largest ring
5.0
QED
0.28
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Influenza Virus
influenza viral neuraminidase
ERK
IKK
JNK
p38 MAPK
STAT
Pathway
Anti-infection
Microbiology&virology
JAK/STAT Signaling
MAPK/ERK Pathway
NF-κB
Stem Cell/Wnt
MOA
Influenza Virus inhibitor
neuraminidase inhibitor
Indication
influenza A virus infection
Solubility
5%TFA: 3 mg/mL (7.84 mM)<br/>DMSO: 0.2 mg/mL (0.52 mM)<br/>Water: Insoluble
Source data