General
Preferred name
LESINURAD
Synonyms
RDEA594 ()
RDEA 594, RDEA-594, RDEA594 ()
Zurampic ()
RDEA-594 ()
RDEA 594 ()
P&D ID
PD016170
CAS
878672-00-5
1151516-14-1
Tags
drug
natural product
available
Approved by
FDA
EMA
First approval
2015
Drug indication
Hyperuricaemia
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Lesinurad is an orally available inhibitor of URAT1, the renal transporter that regulates uric acid excretion from the body .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
19
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
403.0
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
4.24
TPSA
68.01
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
Target
OAT1
OAT3
SLC22A12
OAT
URAT1
Member status
member
Indication
gout
MOA
uric acid diuretic
Source data