General
Preferred name
UCN-01
Synonyms
7-hydroxystaurosporine ()
P&D ID
PD016168
CAS
112953-11-4
Tags
drug candidate
nuisance
natural product
available
Drug indication
Non-small-cell lung cancer
Drug Status
experimental
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
7-hydroxystaurosporine is a cell-permeable derivative, with anticancer activity . It reversibly and ATP-competitively inhibits multiple protein kinases, including PKCα, β, γ, δ and ε , Chk1 , Cdc25C-associated protein kinase 1 (cTAK1) , Cdk1 , PAK4, Cdk5/p25, Chk2 , PDK1 , Lck , p38 MAPK kinase 2 (MAPK14) , Akt, GSK-3β and PKA .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugMAP
Guide to Pharmacology
Nuisance compounds in cellular assays
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
482.2
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
8
Aromatic Ring Count
5
cLogP
3.84
TPSA
89.68
Fraction CSP3
0.32
Chiral centers
5.0
Largest ring
7.0
QED
0.36
Structural alerts
1
Nonspecific kinase inhibiton
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Anticancer Agents
Source data
