General
Preferred name
RETAPAMULIN
Synonyms
SB-275833 ()
Retapamulin ()
Altargo ()
Retapamulina ()
NSC-759885 ()
SB275833 ()
Altabax ()
Sb 275833 ()
Retapamuline ()
P&D ID
PD016155
CAS
224452-66-8
Tags
available
drug
Approved by
FDA
EMA
First approval
2007
Drug Status
approved
Max Phase
4.0
Drug indication
Impetigo
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Retapamulin (SB-275833) is a topical antibiotic that binds Staphylococcus aureus and E. coli ribosomes with a Kd of 3 nM. Retapamulin can be used in researches of atopic dermatitis and prostate cancer[1][2][8].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Pandemic Response Box
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
517.32
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
0
cLogP
5.25
TPSA
66.84
Fraction CSP3
0.87
Chiral centers
11.0
Largest ring
8.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ribosome inhibitor
protein synthesis inhibitor
Indication
impetigo
Target
antibiotic
Bacterial
Antibiotics
Pathway
Anti-infection
Source data
