General
Preferred name
EDOTECARIN
Synonyms
J 107088 ()
PF 804950 ()
PF-804950 ()
J-107088 ()
P&D ID
PD016151
CAS
174402-32-5
Tags
drug candidate
natural product
probe
available
Drug indication
Gastric adenocarcinoma
Drug Status
investigational
Max Phase
Phase 3
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control available, exact structure not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
23
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Edotecarin is a synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
6
Organisms
0
Compound Sets
6
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugMAP
Probe Miner (suitable probes)
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
608.18
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
10
Rotatable Bonds
6
Ring Count
7
Aromatic Ring Count
5
cLogP
-0.73
TPSA
241.2
Fraction CSP3
0.31
Chiral centers
5.0
Largest ring
6.0
QED
0.11
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Topoisomerase
Pathway
Cell Cycle/DNA Damage
Solubility
Soluble in DMSO
Source data