General
Preferred name
nafarelin
Synonyms
RS-94991-298 ()
Nafarelin acetate hydrate ()
Synarel ()
NAFARELIN ACETATE ()
Nafarelin Acetate Hydrate (1:x:x) ()
Nafarelin (acetate) ()
P&D ID
PD016140
CAS
121897-31-2
76932-60-0
76932-56-4
86220-42-0
Tags
available
drug
Approved by
PMDA
FDA
First approval
1990
Drug Status
approved
Drug indication
Endometriosis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Nafarelin is a gonadotropin releasing hormone receptor agonist. The structure shown here is from PubChem CID 25077405.
(GtoPdb)
DESCRIPTION
Nafarelin, under the brand name Synarel, is a gonadotropin-releasing hormone (GnRH) agonist. It can decrease pituitary secretion of the gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin is used in women for the treatment of endometriosis that decreases the abnormal tissue and relieves the symptoms.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
1321.64
Hydrogen Bond Acceptors
15
Hydrogen Bond Donors
17
Rotatable Bonds
33
Ring Count
8
Aromatic Ring Count
6
cLogP
-1.41
TPSA
472.13
Fraction CSP3
0.41
Chiral centers
9.0
Largest ring
6.0
QED
0.01
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Target
GNRHR
Biosynthetic Origin
Peptide (Ribosomal)
Therapeutic Indication
Hormone
Therapeutic Class
Hormone Therapy
Fertility Agents
Source data
