General
Preferred name
ML-099
Synonyms
ML099 ()
496775-95-2 ()
CID-888706 ()
P&D ID
PD016030
CAS
496775-95-2
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
MLP Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A[1].
PRICE 99
DESCRIPTION Recent studies have mainly been focused on the identification of GTPase inhibitors. To our knowledge, small molecule activators of low molecule weight GTPases, with the possible exception of aluminum tetrafluoride which activates the GDP bound form are unknown. (MLP Probes)
DESCRIPTION ML-099 is a pan activator of Ras-related GTPases. (BOC Sciences Bioactive Compounds)
DESCRIPTION ML-099 is a pan Ras-related GTPases activator that activates Rac1, Ras, GTP-binding protein (Rab7), Rab2A and cell division cycle 42. (TargetMol Bioactive Compound Library)
Compound Sets
6
BOC Sciences Bioactive Compounds
ml-099-cas-496775-95-2-291037
Cayman Chemical Bioactives
15176
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
HY-124306
MLP Probes
NBK47359
TargetMol Bioactive Compound Library
T22991
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
259.07
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
2
cLogP
3.11
TPSA
50.19
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Antitarget
Glutathione S-transferase
Target
cdc42 activated mutant
Ras
cell division cycle 42
Rab2A
Rab7
RAC1
Pathway
Cell Cycle/Checkpoint
GPCR/G protein
MAPK
MAPK/ERK Pathway
Source data