General
Preferred name
ML115
Synonyms
ML-115 ()
P&D ID
PD016016
CAS
912798-42-6
Tags
available
probe
Probe info
Probe type
experimental probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ML115 is a molecular probe of the signal transducer and activator of transcription (STAT3). ML115 is a STAT3 agonist[1].
PRICE
279
DESCRIPTION
ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NF??B anti-targets.
DESCRIPTION
Studies showing that STAT3 is activated in breast and prostate cancers, that genetic inhibition of STAT3 reduces cell proliferation, survival, and wound healing (1-3), and that disrupting STAT3-EGFR interactions reduces tumor growth (4), suggest that STAT3 activation has broad cellular effects. As a result, the identification of selective STAT3 modulators may provide useful tools for exploring STAT3 biology.
(MLP Probes)
DESCRIPTION
ML-115 is a potent, cell-permeable STAT3 activator with EC50 value of 2 nM. It is inactive against the related STAT1 and NFκB anti-targets. ML-115 exhibits no cytotoxicity in the parental cell lines in the STAT3 assay (HT-1080) and STAT1 assay (NIH-3T3).
(BOC Sciences Bioactive Compounds)
DESCRIPTION
ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
MLP Probes
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
322.07
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.47
TPSA
73.59
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.91
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Antitarget
STAT1
Target
STAT3
STAT
Pathway
JAK/STAT Signaling
Stem Cells
Stem Cell/Wnt
Source data
