General
Preferred name
ML334
Synonyms
ML 334 ()
LH601A ()
ML-334 ()
P&D ID
PD015841
CAS
1432500-66-7
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 ¦ÌM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2].
PRICE
110
DESCRIPTION
ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proliferation.
DESCRIPTION
ML 334 is an inhibitor of Keap1-Nrf2 interaction. It can affect the cytoprotective responses to oxidative and electrophilic stress.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Inhibitor of phosphatidylcholine transfer protein (PC-TP)
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
MedChem Express Bioactive Compound Library
MLP Probes
MLSMR Probes +
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
446.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
3.3
TPSA
94.99
Fraction CSP3
0.38
Chiral centers
3.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Classification
Probe
Antitarget
Cytotoxicity
Target
KEAP1
NRF2 acitivator
Keap1-Nrf2
Quinone Reductase
Primary Target
Nrf2
MOA
Activator
Inhibitor of KEAP1-nrf2 protein-protein interaction
Erythroid Derived 2, Like 2 (Nrf2) Activators
KEAP1 gene inhibitor
NRF2 Activator
Pathway
NF-¦ÊB
Metabolic Enzyme/Protease
NF-κB
Member status
member
Source data
