General
Preferred name
PD 174265
Synonyms
PD174265 ()
N-{4-[(3-Bromophenyl)amino]quinazolin-6-Yl}propanamide ()
PD-174265 ()
P&D ID
PD015762
CAS
216163-53-0
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
calculated probe
Probe selectivity
protein-selective
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
78
No orthogonal probes found
Similar probes
34
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC50 of 450 pM[1].
PRICE
33
DESCRIPTION
PD 174265 is a cell-permeable, reversible inhibitor of EGFR tyrosine kinase activity with IC50 value of 0.45 nM.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
PD 174265 is an effective, selective and reversible inhibitor of epidermal growth factor receptor (EGFR) with an IC50 of 0.45 nM.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
7
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
370.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
4.48
TPSA
66.91
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
EGFR
Pathway
JAK/STAT Signaling
Protein Tyrosine Kinase/RTK
Angiogenesis
Tyrosine Kinase/Adaptors
Source data
