General
Preferred name
R59949
Synonyms
R-59949 ()
R 59949 ()
R-59-949 ()
DIACYLGLYCEROL KINASE INHIBITOR II ()
P&D ID
PD015753
CAS
120166-69-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC50 of 300 nM. R59949 strongly inhibits the activity of type I DGK ¦Á and ¦Ã and moderately attenuates the activity of type II DGK ¦È and ¦Ê. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol[1][2][3].
PRICE 145
DESCRIPTION This compound inhibits diacylglycerol kinase activity . (GtoPdb)
DESCRIPTION R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) expressed in vascular smooth muscle cells. It inhibits inducible nitric oxide production in vascular smooth muscle cells through decreasing transplasmalemmal L-arginine uptake. (BOC Sciences Bioactive Compounds)
DESCRIPTION R59949 is used as a Diacylglycerol kinase (DGK) inhibitor. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
7
BOC Sciences Bioactive Compounds
4-1h-quinazolinone-3-2-4-bis-4-fluorophenyl-methylene-1-piperidinyl-cas-120166-69-0-item-47475
Cayman Chemical Bioactives
21221
Guide to Pharmacology
5957
LINCS compound set
10470-101
MedChem Express Bioactive Compound Library
HY-108355
Selleckchem Bioactive Compound Library
r59949
TargetMol Bioactive Compound Library
T26019
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
489.17
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
4
cLogP
5.94
TPSA
41.03
Fraction CSP3
0.21
Chiral centers
0.0
Largest ring
6.0
QED
0.35
Structural alerts
1
aggregator (Aggregator Advisor)
Aggregators
Custom attributes
(extracted from source data)
Target
DGK
PKC
Pathway
Chromatin/Epigenetic
Cytoskeletal Signaling
Epigenetics
TGF-beta/Smad
Source data