General
Preferred name
HNMPA-(AM)3
Synonyms
P&D ID
PD015750
CAS
120944-03-8
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 ¦ÌM) and insulin receptor activity (IC50 is 14.2 ¦ÌM and 200 ¦ÌM in mosquitoes and mammals, respectively)[1][2].
DESCRIPTION HNMPA-(AM)3 is a cell-permeable analog of HNMPA, an insulin receptor tyrosine kinase inhibitor (IRTK). It inhibits serine and tyrosine autophosphorylation by the human insulin receptor. (BOC Sciences Bioactive Compounds)
Compound Sets
5
BOC Sciences Bioactive Compounds
hnmpa-am-3-cas-120944-03-8-291217
Cayman Chemical Bioactives
23245
CZ-OPENSCREEN Bioactive Library
DrugMatrix
MedChem Express Bioactive Compound Library
HY-124097
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
454.1
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
0
Rotatable Bonds
11
Ring Count
2
Aromatic Ring Count
2
cLogP
3.64
TPSA
123.66
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.22
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Insulin Receptor
Pathway
Protein Tyrosine Kinase/RTK
Source data