General
Preferred name
JK184
Synonyms
JK 184 ()
HH signaling antagonist vii ()
P&D ID
PD015738
CAS
315703-52-7
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
JK184 is a potent Hedgehog (Hh) pathway inhibitor with IC50 of 30 nM in mammalian cells.
PRICE
59
DESCRIPTION
Alcohol dehydrogenase 7 inhibitor; inhibits downstream Hh signaling pathway
(Tocriscreen Plus)
DESCRIPTION
Downstream Hh signaling pathway inhibitor; inhibits alcohol dehydrogenase 7
(Tocriscreen Total)
DESCRIPTION
JK184, a potent Hedgehog (Hh) pathway inhibitor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
0
Compound Sets
9
Axon Medchem Screening Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
16
Molecular Weight
350.12
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
4
cLogP
4.91
TPSA
51.45
Fraction CSP3
0.16
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Hedgehog
Hedgehog inhibitor
Hedgehog/Smoothened
MOA
Hedgehog pathway inhibitor
Pathway
Stem Cell/Wnt
GPCR/G protein
Stem Cells
Source data
