General
Preferred name
CYCLOPAMINE
Synonyms
11-deoxojervine ()
CHEMBL254129 ()
[3H]-Cyclopamine ()
P&D ID
PD015737
CAS
11051-96-0
4449-51-8
Tags
available
probe
natural product
drug candidate
Drug indication
Discovery agent
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
High-quality chemical probes
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cyclopamine is a SMO antagonist that acts as a potent inhibitor of the Hedgehog (Hh) signaling pathway . It is a natural product present in the roots and rhizomes of Veratrum californicum (corn lily). Multiple structures with alternative stereochemistry are recorded in online chemistry resources.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
52
Organisms
0
Compound Sets
16
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Guide to Pharmacology
High-quality chemical probes
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
Tool Compound Set
Welcome Trust Cancer Drugs
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
32
Molecular Weight
411.31
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
6
Aromatic Ring Count
0
cLogP
5.0
TPSA
41.49
Fraction CSP3
0.85
Chiral centers
10.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Smoothened homolog
SMO
Smoothened
Endogenous Metabolite
Hedgehog
Pathway
GPCR/G protein
Stem Cells
Metabolic Enzyme/Protease
Stem Cell/Wnt
MOA
Hedgehog/Smoothened
Smo Receptor Antagonists
Hedgehog Signaling Inhibitors
"Smo Receptor Antagonists
Hedgehog Signaling Inhibitors"
Hedgehog pathway inhibitor
Member status
member
Source data
