General
Preferred name
Phorbol 12-myristate 13-acetate diester
Synonyms
PMA ()
phorbol 12-myristate 13-acetate ()
PHORBOL MYRISTATE ACETATE ()
12-O-Tetradecanoylphorbol-13-acetate,TPA, Phorbol myristate acetate ()
Phorbol 12-myristate 13-acetate (PMA) ()
TPA ()
Tetradecanoylphorbol acetate ()
Pma (phorbol ester) ()
NSC-262244 ()
Tpa (phorbol ester) ()
PMA (PHORBOL ESTER) ()
TETRADECANOYLPHORBOL ACETATE ()
TPA (PHORBOL ESTER) ()
P&D ID
PD015731
CAS
11016-13-0
16561-29-8
Tags
available
drug candidate
Drug indication
Acute myeloid leukaemia
Myelodysplastic syndrome
Hodgkin lymphoma
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator[1][2]. Phorbol 12-myristate 13-acetate is a NF-¦ÊB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells[3][7].
PRICE 142
DESCRIPTION Phorbol 12-myristate 13-acetate (PMA), a member of the phorbol ester group of natural products, activates PKC, SphK, and NF-??B, and induces THP1 cell differentiation.
DESCRIPTION Phorbol 12-myristate 13-acetate (PMA), a member of the phorbol ester group of natural products, activates PKC, SphK, and NF-κB, and induces THP1 cell differentiation. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
5
Compound Sets
18
Cayman Chemical Bioactives
10008014
ChEMBL Drugs
CHEMBL279115
Concise Guide to Pharmacology 2017/18
2341
Concise Guide to Pharmacology 2019/20
2341
Concise Guide to Pharmacology 2021/22
2341
Concise Guide to Pharmacology 2023/24
2341
Drug Repurposing Hub
DrugBank
DB17045
DrugMAP
DMJWD62
EU-OPENSCREEN Bioactive Compound Library
EOS101011
EUbOPEN Chemogenomics Library
EUB0002077
Guide to Pharmacology
2341
Mcule NIBR MoA Box Subset
MCULE-1325545503
MedChem Express Bioactive Compound Library
HY-18739
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
phorbol-12-myristate-13-acetate
TargetMol Bioactive Compound Library
TQ0198
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
616.4
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
3
Rotatable Bonds
15
Ring Count
4
Aromatic Ring Count
0
cLogP
5.75
TPSA
130.36
Fraction CSP3
0.81
Chiral centers
8.0
Largest ring
7.0
QED
0.12
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NF-κB
PKC
SPHK
KCNT2, TRPV4
PKC,S1P Receptor
Member status
member
MOA
Protein kinase C alpha stimulator
PKC activator
Pathway
Chromatin/Epigenetic
Cytoskeletal Signaling
GPCR/G protein
Epigenetics
Immunology/Inflammation
TGF-beta/Smad
NF-¦ÊB
Recommended Cell Concentration
None
Source data