General
Preferred name
PKR inhibitor
Synonyms
PKR-IN-C16 ()
C16 ()
ASN-11124542 ()
imoxin, C16, Imidazolo-oxindole PKR inhibitor C16 ()
P&D ID
PD015705
CAS
608512-97-6
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This is compound 16 in which has been shown to be an ATP competitive inhibitor blocking autophosphorylation of PKR.
Double-stranded RNA-activated protein kinase (PKR) is also known as eukaryotic initiation factor 2 subunit α (eIF2α). (GtoPdb)
DESCRIPTION Potent RET inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION C16 is an inhibitor of RNA-activated protein kinase (PKR) (IC50 = 210 nM). It is an imidazolo-oxindole derivative that binds to ATP-binding site of PKR and rescues PKR-dependent translation block in vitro. C16 has neuroprotective activity against cell damage in human neuroblastoma cells and neuroinflammation in acute excitotoxic rat model. (BOC Sciences Bioactive Compounds)
Compound Sets
11
AdooQ Bioactive Compound Library
A13538
BOC Sciences Bioactive Compounds
c16-cas-608512-97-6-376217
Cayman Chemical Bioactives
15323
DrugMAP
DMFNZOI
Guide to Pharmacology
6026
Mcule NIBR MoA Box Subset
MCULE-5829692005
MedChem Express Bioactive Compound Library
HY-13977A
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
pkr-in-c16
TargetMol Bioactive Compound Library
T16550
Tocris Bioactive Compound Library
5382
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
268.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
3
cLogP
2.51
TPSA
70.67
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
PKR
Apoptosis related,eIF,Interleukins,PKR
Primary Target
Other Kinases
MOA
Inhibitor
PKR Inhibitor
Member status
member
Pathway
Apoptosis
Source data