General
Preferred name
DIPHENYLENEIODONIUM
Synonyms
DIPHENYLENEIODONIUM CHLORIDE ()
DPI ()
Diphenyleneiodonium chloride (DPI) ()
Diphenyleneiodonium (chloride) ()
P&D ID
PD015695
CAS
4673-26-1
4510-83-2
123773-57-9
4843-42-9
1010-76-0
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This ligand is represented in ChEMBL without the chloride by the entry with ID CHEMBL365739.
(GtoPdb)
DESCRIPTION
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC50 of 1 to 3 ¦ÌM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.
PRICE
43
DESCRIPTION
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 ??M, respectively),and displays broad-spectrum bactericidal activity.
DESCRIPTION
Standard H2 selective agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Endothelial nitric oxide synthase inhibitor
(LOPAC library)
DESCRIPTION
Binds to flavoproteins and inhibits NOS
(Tocriscreen Total)
DESCRIPTION
Diphenyleneiodonium chloride has been found to be a GPR3 agonist and also exhibit inhibition against NO synthase, NADG reductase and NADPH oxidase.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
5
Compound Sets
20
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
278.97
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
2
cLogP
-0.2
TPSA
0.0
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
eNOS
Target
NADPH oxidase
NOS
Reactive Oxygen Species
TRP Channel
NADPH-oxidase,NOS,ROS,TRP Channel
Reactive Oxygen Species (ROS)
Primary Target
Orphan 7-TM Receptors
MOA
Agonist
Cytochrome P450 Inhibitors
NADPH Oxidase Inhibitors
Nitric Oxide Synthase Inhibitors
Xanthine Oxidase Inhibitors
Electron transport chain inhibitor
Pathway
NF-¦ÊB
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
NF-κB
Metabolism
Member status
member
Source data
