General
Preferred name
OTSSP167
Synonyms
OTSSP167, OTS167 ()
OTS-167 ()
MELK inhibitor ()
OTS167 ()
OTSSP167 (hydrochloride) ()
OTS167 (hydrochloride) ()
OTSSP 167 (hydrochloride) ()
P&D ID
PD015651
CAS
1431697-89-0
1431698-10-0
Tags
available
probe
Probe info
Probe type
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Inhibitor, ATP competitive
(Chemical Probes.org)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
28
Organisms
0
Compound Sets
10
Cayman Chemical Bioactives
Chemical Probes.org
Clinical kinase drugs
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
Kinase Inhibitors (best-in-class)
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
20
Molecular Weight
486.16
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
4
Aromatic Ring Count
3
cLogP
6.04
TPSA
78.35
Fraction CSP3
0.4
Chiral centers
0.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
MELK
Known off targets
multiple
Kinase group
CAMK
Pathway
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Member status
member
MOA
MELK inhibitor
maternal embryonic leucine zipper kinase inhibitor
Target class
Protein kinase
Control
Cpd1
Source data
