General
Preferred name
NH-3
Synonyms
P&D ID
PD015623
CAS
447415-26-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3]. NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
PRICE 805
DESCRIPTION NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment. (TargetMol Bioactive Compound Library)
Compound Sets
4
DrugMAP
DMYAB79
Guide to Pharmacology
2633
MedChem Express Bioactive Compound Library
HY-141513
TargetMol Bioactive Compound Library
T40548
External IDs
12
Properties
(calculated by RDKit )
Molecular Weight
473.18
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
5.49
TPSA
109.9
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.27
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
thyroid hormone
Thyroid hormone receptor
Pathway
Endocrinology/Hormones
Vitamin D Related/Nuclear Receptor
Source data