General
Preferred name
hyperforin
Synonyms
CHEMBL501711 ()
Hyperforin dicyclohexylammonium salt ()
Hyperforin DCHA ()
P&D ID
PD015600
CAS
11079-53-1
238074-03-8
Tags
available
probe
drug candidate
Drug indication
Discovery agent
Probe info
Probe type
calculated probe
Probe sources
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Hyperforin is a principal ingredient of Hypericum perforatum (St. John's wort). Hyperforin activates TRPC6 channel to inhibit the reuptake of serotonin, suggesting its potential use as an antidepressant. It also exhibits antibacterial effects.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
4
BOC Sciences Bioactive Compounds
DrugMAP
NURSA ligand set
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
536.39
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
11
Ring Count
2
Aromatic Ring Count
0
cLogP
8.99
TPSA
71.44
Fraction CSP3
0.63
Chiral centers
4.0
Largest ring
6.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Pregnane X receptor
Source data
