General
Preferred name
Alpha-Estradiol
Synonyms
17α-estradiol ()
Alfatradiol ()
Epiestrol ()
Epiestradiol ()
α-Estradiol ()
MX-4509 ()
¦Á-Estradiol, 17alpha-Estradiol, Alfatradiol, Epiestradiol, Epiestrol, Alora, 17 ¦Á-E2 ()
17.alpha.-Estradiol ()
17α-estradiol ()
Estradiol, alpha- ()
.alpha.-estradiol ()
Estradiol, .alpha.- ()
17a-estradiol ()
17ALPHA-ESTRADIOL ()
Estradiol 17-.alpha. ()
P&D ID
PD015587
CAS
57-91-0
50-28-2
Tags
available
drug candidate
Drug indication
Neurological disorder
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Alpha-Estradiol is a weak estrogen and a 5¦Á-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.
PRICE
29
DESCRIPTION
17α-Estradiol is a minor and weak endogenous steroidal estrogen. It is the C17 epimer of estradiol.
(GtoPdb)
DESCRIPTION
Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Endogenous ER agonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
13
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
DrugMAP
Guide to Pharmacology
Ki Database
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NURSA ligand set
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
272.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
1
cLogP
3.61
TPSA
40.46
Fraction CSP3
0.67
Chiral centers
5.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-α reductase
Endogenous Metabolite
ERα
ERβ
5 alpha Reductase
Bacterial
Estrogen/progestogen Receptor
Primary Target
Estrogen and Related Receptors
MOA
Agonist
"Estrogen Receptor (ER) Agonists
Steroid 5alpha-Reductase Inhibitors"
Estrogen Receptor (ER) Agonists
Steroid 5alpha-Reductase Inhibitors
Member status
member
Pathway
Endocrinology/Hormones
Metabolism
Anti-infection
Metabolic Enzyme/Protease
Source data
