General
Preferred name
EPROTIROME
Synonyms
KB2115 ()
Eprotirome (KB2115) ()
Bms-356384 ()
KB-2115 ()
Eprotiromo ()
P&D ID
PD015583
CAS
355129-15-6
Tags
available
drug candidate
Drug Status
investigational
Max Phase
3.0
Drug indication
Familial hypercholesterolemia
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
KB2115 works by selectively stimulating the thyroid hormone; receptor which is the protein in the body that mediates the effects of thyroid hormone. KB2115 has receptor and tissue selective properties and thereby negative effects on the heart can be avoided.
DESCRIPTION
Eprotirome (KB2115) is a liver-selective thyroid hormone receptor (TR) agonist. KB2115 has modestly higher affinity for TR¦Â than for TR¦Á. Eprotirome reduces low-density lipoprotein (LDL) cholesterol concentrations. Eprotirome can be used for dyslipidemias and obesity research[1][2].
PRICE
347
DESCRIPTION
Eprotirome (KB2115), a synthetic thyroid hormone mimetic, is a thyroid hormone receptor agonist.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
Cayman Chemical Bioactives
ChEMBL Drugs
DrugBank
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NURSA ligand set
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
484.95
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
5.25
TPSA
95.86
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
THR
Thyroid hormone receptor
MOA
Thyroid hormone receptor(THR)
Pathway
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Source data
