General
Preferred name
MURISTERONE A
Synonyms
Muristerone ()
P&D ID
PD015500
CAS
38778-30-2
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Muristerone A, a phytoecdysteroid analog of ecdysone, acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
NURSA ligand set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
496.3
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
7
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
0
cLogP
0.82
TPSA
158.68
Fraction CSP3
0.89
Chiral centers
11.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
