General
Preferred name
L-azetidine-2-carboxylic acid
Synonyms
(2S)-azetidine-2-carboxylic acid ()
L-2-Azetidinecarboxylic acid ()
L-azetidine-2-carboxylate ()
P&D ID
PD015487
CAS
2133-34-8
Tags
available
natural product
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Azetidine-2-carboxylic acid is a plant-derived non-protein amino acid homologue of proline. It has been identified in lily of the valley, solomon's seal and bean plants.
(GtoPdb)
DESCRIPTION
L-Azetidine-2-carboxylic acid is an endogenous metabolite. It inhibits kallikrein-related peptidases 5 (KLK5) and 7 (KLK7).
(Enamine Bioactive Compounds)
DESCRIPTION
Inhibits collagen synthesis
(LOPAC library)
DESCRIPTION
L-Azetidine-2-carboxylic acid ((2S)-azetidine-2-carboxylic acid) is a toxic proline analogue produced by members of the Liliaceae and Agavaciae families.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
12
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Enamine Bioactive Compounds
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
101.05
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
-0.57
TPSA
49.33
Fraction CSP3
0.75
Chiral centers
1.0
Largest ring
4.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Collagen
Target
Human Endogenous Metabolite
Apoptosis
ATF6
Atg8/LC3
Autophagy
Bcl-2 Family
Endogenous Metabolite
Eukaryotic Initiation Factor (eIF)
PERK
Pathway
Metabolism
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Source data
