General
Preferred name
DL-AP4
Synonyms
(±)-2-Amino-4-phosphonobutyric acid ()
L(+)-2-AMINO-4-PHOSPHONOBUTYRIC ACID ()
D-(-)-2-AMINO-4-PHOSPHONO-BUTYRIC ACID ()
DL-2-AMINO-4-PHOSPHONOBUTYRIC ACID ()
L-APB ()
L-AP4 ()
4-Amino Phosphonobutyrate ()
2-Amino-4-phosphono-butyric acid ()
2-Amino-4-phosphonobutyric acid ()
DL-AP4 Sodium salt ()
P&D ID
PD015468
CAS
6323-99-5
20263-07-4
1263093-79-3
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Broad spectrum glutamatergic antagonist (Tocris Bioactive Compound Library)
DESCRIPTION NMDA glutamate receptor antagonist (LOPAC library)
DESCRIPTION DL-AP4 has been found to be a broad spectrum EAA ligand as well as an NMDA glutamate receptor antagonist. (BOC Sciences Bioactive Compounds)
DESCRIPTION The sodium salt form of DL-AP4, which has been found to be a broad spectrum EAA ligand. (BOC Sciences Bioactive Compounds)
Compound Sets
13
BOC Sciences Bioactive Compounds
dl-ap4-cas-20263-07-4-366048
dl-ap4-sodium-salt-cas-1263093-79-3-item-169759
Cayman Chemical Bioactives
29011
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMOIZY1
DrugMatrix
EUbOPEN Chemogenomics Library
EUB0000356
Ki Database
4-Amino Phosphonobutyrate
L-AP4
L-APB
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-3863533502
MedChem Express Bioactive Compound Library
HY-100743
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
Tocris Bioactive Compound Library
0101
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
183.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.03
TPSA
120.85
Fraction CSP3
0.75
Chiral centers
1.0
Largest ring
0.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA
Primary Target
Non-selective Ionotropic Glutamate
MOA
Antagonist
mgluR6 Antagonists
Member status
member
Pathway
GPCR/G protein
Neuronal Signaling
Recommended Cell Concentration
100 nM
Target
mGluR
Source data