General
Preferred name
p-Aminobenzamidine dihydrochloride
Synonyms
4-Aminobenzamidine dihydrochloride ()
4-Aminobenzamidine (dihydrochloride) ()
p-Aminobenzamidine (dihydrochloride) ()
P&D ID
PD015463
CAS
2498-50-2
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor. 4-Aminobenzamidine dihydrochloride acts as an orally active urokinase type plasminogen activator (uPA) inhibitor (Ki=82 ¦ÌM). 4-Aminobenzamidine dihydrochloride can be used for cardiovascular diseases and anti-tumor study[1][2][3][4].
PRICE
29
DESCRIPTION
4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 ??M). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice [1] [2].
DESCRIPTION
Trypsin inhibitor; competitive kallikrein inhibitor
(LOPAC library)
DESCRIPTION
4-Aminobenzamidine dihydrochloride (p-Aminobenzamidine dihydrochloride) is a strong trypsin inhibitor and a relatively weak inhibitor of urokinase type plasminogen activator (uPA) (K i =82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice [1] [2].
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
3
LOPAC library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
207.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.4
TPSA
75.89
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.37
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Trypsin
Target
trypsin
PAI-1
Ser/Thr Protease
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data
