General
Preferred name
PD015460
Synonyms
2-Hydroxysaclofen ()
2-hydroxy-saclofen ()
P&D ID
PD015460
CAS
117354-64-0
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION GABA-B receptor antagonist (LOPAC library)
DESCRIPTION Selective GABAB antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective GABAB antagonist, more potent than Cat. No. 0246 (Tocriscreen Total)
DESCRIPTION 2-Hydroxysaclofen is a GABAB receptor antagonist. (BOC Sciences Bioactive Compounds)
Compound Sets
11
BOC Sciences Bioactive Compounds
2-hydroxysaclofen-cas-117354-64-0-359670
Concise Guide to Pharmacology 2017/18
1068
Concise Guide to Pharmacology 2019/20
1068
Concise Guide to Pharmacology 2021/22
1068
Concise Guide to Pharmacology 2023/24
1068
DrugMAP
DMHO8KQ
DrugMatrix
Guide to Pharmacology
1068
LOPAC library
Tocris Bioactive Compound Library
0245
Tocriscreen Total
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
265.02
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
0.37
TPSA
100.62
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
GABA-B
Primary Target
GABAB Receptors
MOA
Antagonist
Source data