General
Preferred name
D-AP7
Synonyms
D(-)-2-Amino-7-phosphonoheptanoic acid ()
(R)-2-Amino-7-phosphono-heptanoic acid ()
P&D ID
PD015406
CAS
81338-23-0
Tags
drug candidate
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
NMDA glutamate receptor antagonist
(LOPAC library)
DESCRIPTION
D-AP7 is a selective NMDA receptor antagonist that inhibits the glutamate binding site and activation of NMDA receptor. It is the 8-Bromo-cGMP and the more active form of DL-AP7. It shows anticonvulsant and anxiogenic-like effects.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
225.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
0.14
TPSA
120.85
Fraction CSP3
0.86
Chiral centers
1.0
Largest ring
0.0
QED
0.36
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA
Source data
