General
Preferred name
PD015402
Synonyms
3-bromo-7-Nitroindazole ()
3-bromo-7-nitro-1H-indazole ()
3-bromo-7NI ()
P&D ID
PD015402
CAS
74209-34-0
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1].
PRICE 29
DESCRIPTION Protein kinase C inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Nitric oxide synthase (NOS) inhibitor (LOPAC library)
DESCRIPTION Selective nNOS inhibitor (Tocriscreen Total)
DESCRIPTION 3-Bromo-7-nitroindazole has been found to be a nNOS inhibitor and could also be a neuroprotective compound that inhibits the endoplasmic reticulum stress pathway. (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective nNOS inhibitor (Tocriscreen Plus)
DESCRIPTION An inhibitor of Neuronal NOS  with IC50 = 0.17 µM (Enamine Bioactive Compounds)
DESCRIPTION 3-Bromo-7-nitroindazole is a specific neuronal nitric oxide synthase (nNOS) inhibitor that affects the synthesis of the intercellular messenger NO throughout the brain and body. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
0
Compound Sets
19
BOC Sciences Bioactive Compounds
3-bromo-7-nitroindazole-cas-74209-34-0-item-132078
Cayman Chemical Bioactives
81345
Concise Guide to Pharmacology 2017/18
5113
Concise Guide to Pharmacology 2019/20
5113
Concise Guide to Pharmacology 2021/22
5113
Concise Guide to Pharmacology 2023/24
5113
Drug Repurposing Hub
DrugBank
DB01997
DrugMAP
DMM7DHB
DrugMatrix
Enamine Bioactive Compounds
EBC-48117
EU-OPENSCREEN Bioactive Compound Library
EOS102321
Guide to Pharmacology
5113
LOPAC library
MedChem Express Bioactive Compound Library
HY-101175
TargetMol Bioactive Compound Library
T10107
Tocris Bioactive Compound Library
0735
Tocriscreen Plus
0735
Tocriscreen Total
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
240.95
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
2.23
TPSA
71.82
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
NOS
Target
nNOS
NOS1, NOS2, NOS3
NO Synthase
MOA
Inhibitor
nitric oxide synthase inhibitor
Pathway
Immunology/Inflammation
Source data