General
Preferred name
DFMO
Synonyms
DL-alpha-Difluoromethylornithine hydrochloride ()
¦Á-difluoromethylornithine hydrochloride ()
??-difluoromethylornithine hydrochloride ()
Eflornithine (hydrochloride) ()
DFMO hydrochloride ()
MDL71782 hydrochloride ()
RMI71782 hydrochloride ()
α-difluoromethylornithine hydrochloride ()
EFLORNITHINE HYDROCHLORIDE ()
P&D ID
PD015380
CAS
68278-23-9
96020-91-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Eflornithine hydrochloride is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase. Eflornithine is a medication for the treatment of African trypanosomiasis and excessive facial hair growth in women.
DESCRIPTION Selective irreversible ornithine decarboxylase (ODC) inhibitor. (LOPAC library)
DESCRIPTION Eflornithine hydrochloride is a drug found to be effective in the treatment of facial hirsutism. It is a "suicide inhibitor," irreversibly binding to Ornithine Decarboxylase (ODC) and preventing the natural substrate ornithine from accessing the active site. (BOC Sciences Bioactive Compounds)
DESCRIPTION IGF1R inhibitor (Tocris Bioactive Compound Library)
Compound Sets
4
BOC Sciences Bioactive Compounds
eflornithine-hydrochloride-cas-68278-23-9-item-84-75113
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0744A
Tocris Bioactive Compound Library
2761
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
218.06
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
0.19
TPSA
89.34
Fraction CSP3
0.83
Chiral centers
1.0
Largest ring
0.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
ODC
Primary Target
Decarboxylases
MOA
Inhibitor
Target
Parasite
Pathway
Anti-infection
Source data