General
Preferred name
EDELFOSINE
Synonyms
ET-18-OCH3 ()
Edelfosine ()
(R)-EDELFOSINE ()
2-O-methyl PAF C-18 (hydrate) ()
P&D ID
PD015379
CAS
70641-51-9
77286-66-9
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Phosphoinositide-specific Phospholipase C (PI-PLC) inhibitor
(LOPAC library)
DESCRIPTION
Edelfosine is a synthetic lysophospholipid analogue that acts as an inhibitor of phosphatidylinositol phospholipase C (IC50 = 9.6 μM in fibroblasts and adenocarcinoma cells) and an agonist at platelet-activating factor (PAF) receptors. Edelfosine induces apoptosis in human promyelocytic HL-60 leukemic cells and promonocytic U937 leukemic cells.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
13
Organisms
0
Compound Sets
4
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
LOPAC library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
523.4
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
27
Ring Count
0
Aromatic Ring Count
0
cLogP
6.49
TPSA
77.05
Fraction CSP3
1.0
Chiral centers
2.0
Largest ring
0.0
QED
0.07
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
PIPLC
Solubility
In vitro:<br/>10 mM in DMSO
Source data