General
Preferred name
Ro 20-1724
Synonyms
Ro-20-1724 ()
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone ()
Ro20-1724 ()
RO 201724 ()
Ro 20-174 ()
RO-201724 ()
P&D ID
PD015356
CAS
29925-17-5
Tags
available
drug candidate
Drug indication
Asthma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].
PRICE 42
DESCRIPTION Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 ??M and Ki of 3.1 ??M.
DESCRIPTION Potent and selective cAMP phosphodiesterase inhibitor (LOPAC library)
DESCRIPTION Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). It weakly inhibits PDE3 with a Ki value greater than 25 µM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. (BOC Sciences Bioactive Compounds)
DESCRIPTION PDE4 inhibitor (Tocriscreen Plus)
DESCRIPTION PDE4 inhibitor (Tocriscreen Total)
DESCRIPTION Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM. (TargetMol Bioactive Compound Library)
DESCRIPTION Myosin light chain kinase inhibitor (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
22
BOC Sciences Bioactive Compounds
ro-20-1724-cas-29925-17-5-item-62964
Cayman Chemical Bioactives
18272
Concise Guide to Pharmacology 2017/18
5258
Concise Guide to Pharmacology 2019/20
5258
Concise Guide to Pharmacology 2021/22
5258
Concise Guide to Pharmacology 2023/24
5258
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM0PSCF
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS102292
Guide to Pharmacology
5258
JUMP-Target 1 Compound Set
5087
Ki Database
RO 20-1724
LOPAC library
MedChem Express Bioactive Compound Library
HY-100927
ReFrame library
Selleckchem Bioactive Compound Library
ro-20-1724
TargetMol Bioactive Compound Library
T19706
The Spectrum Collection
Tocris Bioactive Compound Library
0415
Tocriscreen Plus
0415
Tocriscreen Total
External IDs
28
Properties
(calculated by RDKit )
Molecular Weight
278.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
1
cLogP
2.1
TPSA
59.59
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
cAMP phosphodiesterase
Target
PDE4
PDE3A
PDE
Phosphodiesterase (PDE)
Primary Target
Phosphodiesterases
MOA
Inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data