General
Preferred name
DAPH
Synonyms
CGP 52411 ()
ICX5609209 ()
CGP52411 ()
CGP-52411 ()
4,5-Dianilinophthalimide ()
P&D ID
PD015342
CAS
145915-58-8
Tags
available
drug candidate
Drug indication
Solid tumour/cancer
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Protein tyrosine kinase inhibitor, specific for EGFR; Also inhibits amyloid beta fibril formation. (LOPAC library)
DESCRIPTION EGFR inhibitor. Also inhibits Abeta42 fibril formation (Tocriscreen Plus)
DESCRIPTION GLP and G9a inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION EGFR inhibitor. Also inhibits Aβ42 fibril formation (Tocriscreen Total)
Cell lines
1
Organisms
2
Compound Sets
9
Cayman Chemical Bioactives
29196
Drug Repurposing Hub
DrugMAP
DMIWUFC
DrugMatrix
LOPAC library
MedChem Express Bioactive Compound Library
HY-103442
Tocris Bioactive Compound Library
3360
Tocriscreen Plus
3360
Tocriscreen Total
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
329.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
3
cLogP
4.06
TPSA
70.23
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzyme-Linked Receptors
Selectivity
EGFR
MOA
Inhibitor
EGFR inhibitor
Target
Amyloid-¦Â
Amyloid-β
Pathway
JAK/STAT Signaling
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Source data