General
Preferred name
SB 204741
Synonyms
SB-204741 ()
SB204741 ()
P&D ID
PD015337
CAS
152239-46-8
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 5-HT2B serontonin receptor antagonist. (LOPAC library)
DESCRIPTION Potent and selective 5-HT4 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95) with ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
11
BOC Sciences Bioactive Compounds
sb-204741-cas-152239-46-8-item-92263
Cayman Chemical Bioactives
32965
DrugMAP
DM3LQF4
DrugMatrix
Guide to Pharmacology
221
Ki Database
SB204741
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-5050089759
MedChem Express Bioactive Compound Library
HY-103153
Novartis Chemogenetic Library (NIBR MoA Box)
Tocris Bioactive Compound Library
1372
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
286.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
3.59
TPSA
58.95
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
5-HT2B
Primary Target
5-HT2B Receptors
MOA
Antagonist
HTR2B antagonist
Member status
virtual
Pathway
GPCR/G protein
Neuronal Signaling
Target
5-HT Receptor
Source data