General
Preferred name
CALCIMYCIN
Synonyms
A23187, free acid ()
A23187 (hydrate) ()
Calcimycin (hydrate) ()
A-23187 ()
Antibiotic A-23187 ()
A23187 ()
A23187 (calcium magnesium salt) ()
P&D ID
PD015310
CAS
52665-69-7
Tags
drug candidate
natural product
available
Drug Status
investigational
Max Phase
Phase 2
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Disrupts microtubules
(Tocris Bioactive Compound Library)
DESCRIPTION
Ca2+ ionophore used to potentiate responses to NMDA, but not quisqualate glutamate receptors
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
4
Compound Sets
7
ChEMBL Drugs
LOPAC library
MedChem Express Bioactive Compound Library
Other bioactive compounds
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
523.27
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
5
Aromatic Ring Count
3
cLogP
5.53
TPSA
126.68
Fraction CSP3
0.55
Chiral centers
7.0
Largest ring
6.0
QED
0.35
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Ca2+
Primary Target
General Calcium Signaling Agents
Target
Apoptosis
Autophagy
antibiotic
Bacterial
Fungal
Pathway
Anti-infection
Source data
