General
Preferred name
Imetit dihydrobromide
Synonyms
Imetit (dihydrobromide) ()
VUF 8325 (dihydrobromide) ()
SKF 91105 (dihydrobromide) ()
Imetit (hydrobromide) ()
P&D ID
PD015268
CAS
32385-58-3
102203-18-9
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Potent and selective H3 histamine receptor agonist
(LOPAC library)
DESCRIPTION
High affinity melatonin agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Standard H3 and H4 agonist (H3 > H4)
(Tocriscreen Total)
DESCRIPTION
Imetit dihydrobromide is a potent and high affinity agonist at histamine H3 and H4 receptors (Ki = 0.3 and 2.7 nM, respectively). It induces an eosinophil shape change (EC50 = 25 nM).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
LOPAC library
MedChem Express Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
14
Molecular Weight
329.91
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
1.73
TPSA
78.55
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
5.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H3
Primary Target
Histamine H3 Receptors
MOA
Agonist
Target
H3 agonist
Histamine Receptor
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data
