General
Preferred name
PD015221
Synonyms
4-DAMP methiodide ()
4-DAMP ()
P&D ID
PD015221
CAS
1952-15-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
M3 muscarinic acetylcholine receptor antagonist.
(LOPAC library)
DESCRIPTION
Selective kappa agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Muscarinic M3 antagonist
(Tocriscreen Total)
DESCRIPTION
4-DAMP is a potent and selective antagonist of the M3 cholinergic receptor. [3H]-4-DAMP selectively labels M1 and M3 receptors. Blockade of mAChR M2 leads to a decrease of blood pressure in dose manner in spotaneously hypertensive rats.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
7
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugMAP
DrugMatrix
LOPAC library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
10
Molecular Weight
451.1
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
0.6
TPSA
26.3
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
M3
Primary Target
M3 Receptors
MOA
Antagonist
Source data
