General
Preferred name
FUREGRELATE SODIUM
Synonyms
U-63557A ()
Furegrelate (sodium) ()
Furegrelate sodium salt ()
Furegrelate (sodium salt) ()
FUREGRELATE ()
P&D ID
PD015186
CAS
85666-17-7
87463-91-0
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent[1][2].
PRICE 31
DESCRIPTION Furegrelate is a potent inhibitor of thromboxane synthase. It has minimal effect on other arachidonate metabolic enzymes. (GtoPdb)
DESCRIPTION Thromboxane synthetase inhibitor (LOPAC library)
DESCRIPTION Furegrelate is a selective and potent inhibitor of thromboxane synthase with an IC50 value of 15 nM for human platelet microsomal thromboxane synthase. (BOC Sciences Bioactive Compounds)
DESCRIPTION Furegrelate sodium (U-63557A) is a selective thromboxane synthase inhibitor with oral activity. Furegrelate sodium(U-63557A) inhibits thromboxane A2 (TXA2) synthase in human platelet microsomes with an IC50 of 15 nM. (TargetMol Bioactive Compound Library)
Compound Sets
9
BOC Sciences Bioactive Compounds
u-63557a-cas-85666-17-7-item-70933
Cayman Chemical Bioactives
70540
Concise Guide to Pharmacology 2021/22
11378
Concise Guide to Pharmacology 2023/24
11378
EUbOPEN Chemogenomics Library
EUB0001816
Guide to Pharmacology
11378
LOPAC library
MedChem Express Bioactive Compound Library
HY-106080A
TargetMol Bioactive Compound Library
T11339
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
275.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
3
cLogP
-1.21
TPSA
66.16
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.56
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Thromboxane synthase
Target
TXA2R
Prostaglandin Receptor
Pathway
DNA Damage/DNA Repair
Metabolism
GPCR/G protein
Recommended Cell Concentration
None
Source data