General
Preferred name
NS 8593 hydrochloride
Synonyms
NS8593 hydrochloride ()
NS8593 HCl ()
NS8593 (hydrochloride) ()
NS8593?Hydrochloride ()
NS-8593 ()
NS 8593 (hydrochloride) ()
P&D ID
PD015184
CAS
875755-24-1
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
NS8593 hydrochloride is a potent and selective small conductance Ca2+-activated K+ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a Kd value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca2+-dependently (Kds of 0.42, 0.60, and 0.73 ¦ÌM, respectively, at 0.5 ¦ÌM Ca2+), and does not affect the Ca2+-activated K+ channels of intermediate and large conductance (hIK and hBK channels, respectively)[1][2].
PRICE
100
DESCRIPTION
Blocks small conductance Ca2+ activated K+ channels
(LOPAC library)
DESCRIPTION
NS8593 HCl is a selective KCa2 channel negative modulator.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective KCa2 (SK) channel negative modulator; inhibits SK currents
(Tocriscreen Plus)
DESCRIPTION
NS8593 hydrochloride (NS8593 HCl) is a potent and selective inhibitor of small conductance Ca2+-activated K+ channels (SK channels) .
(TargetMol Bioactive Compound Library)
DESCRIPTION
TRPM8 blocker
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
EUbOPEN Chemogenomics Library
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
10
Molecular Weight
299.12
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
3
cLogP
4.47
TPSA
40.71
Fraction CSP3
0.24
Chiral centers
1.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
SK(Ca)
Target
Potassium Channel
SK channels
Primary Target
Calcium-Activated Potassium (KCa) Channels
MOA
Modulator
Pathway
Membrane Transporter/Ion Channel
Recommended Cell Concentration
10 uM
Source data
