General
Preferred name
GW7647
Synonyms
GW 7647 ()
CHEMBL21241 ()
GW-7647 ()
GW647 ()
P&D ID
PD015179
CAS
265129-71-3
Tags
drug candidate
natural product
probe
available
Drug indication
Discovery agent
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
experimental probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Agonist
(Chemical Probes.org)
DESCRIPTION
Potent agonist of peroxisome proliferator-activated alpha (PPAR-alpha)
(LOPAC library)
DESCRIPTION
Highly selective, potent PPARalpha agonist. Orally active
(Tocriscreen Plus)
DESCRIPTION
Endogenous agonist for the transcription factor aryl hydrocarbon receptor
(Tocris Bioactive Compound Library)
DESCRIPTION
Highly selective, potent PPARα agonist. Orally active
(Tocriscreen Total)
DESCRIPTION
GW 7647 is a potent and highly selective PPARα agonist (EC50 = 6, 1100 and 6200 nM for human PPARα, PPARγ and PPARδ receptors, respectively) with 200-fold selectivity over PPARγ and PPARδ. GW 7647 modulates oleate metabolism and mitochondrial enzyme gene expression in mature myotubules in vitro via activating PPARα. GW 7647 exhibits lipid-lowering and anti-inflammatory effects.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
25
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Chemical Probes.org
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
High-quality chemical probes
LINCS compound set
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Tool Compound Set
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
502.32
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
12
Ring Count
3
Aromatic Ring Count
1
cLogP
7.28
TPSA
69.64
Fraction CSP3
0.72
Chiral centers
0.0
Largest ring
6.0
QED
0.23
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Nuclear Receptors
Selectivity
PPAR-alpha
Target
Peroxisome proliferator-activated receptor alpha
PPAR??
PPARA
PPARa agonist
PPAR
Pathway
Metabolism
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Vitamin D Related/Nuclear Receptor
Primary Target
PPAR?
MOA
Agonist
PPAR receptor agonist
Target class
Nuclear Hormone Receptor
Target subclass
Nuclear receptor 1C1
Source data
