General
Preferred name
FG 7142
Synonyms
N-Methyl-beta-carboline-3-carboxamide ()
ZK 39106 ()
LSU-65 ()
FG-7142 ()
P&D ID
PD015177
CAS
78538-74-6
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION FG 7142 (ZK 39106; LSU-65), a non-selectively benzodiazepine inverse agonist, has high affinity for the ¦Á1 subunit-containing GABAA receptor (Ki=91 nM). FG 7142 (ZK 39106; LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the ¦Á1 subunit (EC50= 137 nM). FG 7142 (ZK 39106; LSU-65) can increase tyrosine hydroxylation and cause upregulation of ¦Â-adrenoceptors in mouse cerebral cortex[1].
PRICE 53
DESCRIPTION FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the ??1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of ??-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the ??1 subunit-containing GABAA receptor (Ki=91 nM).
DESCRIPTION Kir6 channel (KATP) opener (Tocris Bioactive Compound Library)
DESCRIPTION Benzodiazepine inverse agonist (Tocriscreen Plus)
DESCRIPTION GABA-A receptor antagonist (LOPAC library)
DESCRIPTION Benzodiazepine inverse agonist (Tocriscreen Total)
DESCRIPTION FG 7142 is a benzodiazepine inverse agonist and anxiogenic agent. FG 7142 increases tyrosine hydroxylation and upregulates β-adrenoceptors in mouse cerebral cortex. (BOC Sciences Bioactive Compounds)
DESCRIPTION FG 7142 (LSU-65) also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142 , a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM). (TargetMol Bioactive Compound Library)
Compound Sets
13
BOC Sciences Bioactive Compounds
fg-7142-cas-78538-74-6-item-33105
Cayman Chemical Bioactives
29183
Drug Repurposing Hub
DrugMatrix
Ki Database
FG 7142
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-1827591360
MedChem Express Bioactive Compound Library
HY-100991
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T11277
Tocris Bioactive Compound Library
0554
Tocriscreen Plus
0554
Tocriscreen Total
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
225.09
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
2.08
TPSA
57.78
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
GABA-A
Target
GABA Receptor
GABAA
Primary Target
GABAA Receptors
MOA
Benzodiazepine
GABA(A) BZ Site Receptor Inverse Agonists
GABA benzodiazepine site receptor inverse agonist
Member status
member
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data