General
Preferred name
JX 401
Synonyms
JX401 ()
WAY-300628 ()
JX-401 ()
P&D ID
PD015173
CAS
349087-34-9
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Antimalarial; inhibits P-type ATPase (PfATP6) of P.falciparum
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, reversible p38alpha inhibitor
(Tocriscreen Plus)
DESCRIPTION
Potent, non-cytotoxic, membrane permeable p38a MAPK inhibitor.
(LOPAC library)
DESCRIPTION
Potent, reversible p38α inhibitor
(Tocriscreen Total)
DESCRIPTION
JX 401, cell-permeable piperidinamide compound, is a reversible and highly potent inhibitor of p38α isoform MAP kinase containing a 4-benzylpiperidine motif. Its IC50 value is 32 nM and displays no activity on the p38γ isoform. It effectively blocks the differentiation of L8 myoblasts to myotubes in a reversible manner and blocks the differentiation of myoblasts and myotubes in mammalian cells in culture. It is not a competitive inhibitor with respect to either ATP or substrate. It is hyperactive in inflammatory diseases and may reverse inflammation.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
8
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
LOPAC library
Selleckchem Bioactive Compound Library (Provided by Pfizer)
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
355.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
4.51
TPSA
29.54
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Selectivity
p38a MAPK
Primary Target
p38 MAPK
MOA
Inhibitor
p38 MAPK inhibitor
Target
MAPK14
Source data
