General
Preferred name
MECAMYLAMINE HYDROCHLORIDE
Synonyms
Inversine ()
Mevasin ()
Mecamylamine (hydrochloride) ()
Mecamylamine hcl ()
Mecamylamine chloride ()
NSC-757086 ()
P&D ID
PD015163
CAS
826-39-1
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antihypertensive
First approval
1956
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nicotinic acetylcholine receptor antagonist (LOPAC library)
DESCRIPTION Cognitive enhancer (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
11
Cayman Chemical Bioactives
14602
ChEMBL Approved Drugs
CHEMBL1237082
ChEMBL Drugs
CHEMBL1237082
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS102298
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1395
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
A
TargetMol Bioactive Compound Library
T2141
Tocris Bioactive Compound Library
2843
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
203.14
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
0
cLogP
2.84
TPSA
12.03
Fraction CSP3
1.0
Chiral centers
3.0
Largest ring
5.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Nicotinic
Pathway
Neuroscience
GPCR/G protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Neuronal Signaling
Target
nAChR
Histamine Receptor
AChR
Primary Target
Nicotinic Receptors (Non-selective)
MOA
Antagonist
Source data