General
Preferred name
NS-1619
Synonyms
NS 1619 ()
NS1619 ()
P&D ID
PD015139
CAS
153587-01-0
Tags
drug candidate
natural product
available
Drug indication
Asthma
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective large conductance Ca2+-activated K+-channel activator (LOPAC library)
DESCRIPTION Kir6 (KATP) channel blocker (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
18
AdooQ Bioactive Compound Library
A15975
Axon Medchem Screening Library
2854
Cayman Chemical Bioactives
18876
Concise Guide to Pharmacology 2017/18
4272
Concise Guide to Pharmacology 2019/20
4272
Concise Guide to Pharmacology 2021/22
4272
Concise Guide to Pharmacology 2023/24
4272
DrugMAP
DMES0OT
Guide to Pharmacology
4272
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-3900047859
MedChem Express Bioactive Compound Library
HY-12496
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
ns-161
TargetMol Bioactive Compound Library
T3102
Tocris Bioactive Compound Library
3804
ZINC Tool Compounds
ZINC000009225331
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
362.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
4.06
TPSA
58.02
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
Ca2+ activated
Pathway
Membrane Transporter/Ion Channel
Apoptosis
Target
Potassium Channel
BK channel activator
Primary Target
Calcium-Activated Potassium (KCa) Channels
MOA
Activator
Large Conductance K(Ca) 1.1 (BK, maxi K+) Channel Activators
Member status
member
Source data