General
Preferred name
FPL 64176
Synonyms
FPL64176 ()
FPL-64176 ()
P&D ID
PD015129
CAS
120934-96-5
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM[1][2].
PRICE 98
DESCRIPTION Potent, selective and competitive NMDA antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Potent activator of Ca2+ channels (L-type) (Tocriscreen Plus)
DESCRIPTION Potent L-type Ca2+ channel activator (LOPAC library)
DESCRIPTION FPL 64176 is a potent L-type Ca2+ channel activator (EC50 = 16 nM) displaying 40-fold potency against Bay K 8644 as a positive inotrope in guinea pig atria. (BOC Sciences Bioactive Compounds)
DESCRIPTION Potent activator of Ca2+ channels (L-type) (Tocriscreen Total)
DESCRIPTION FPL64176 is a L-type calcium channels activator. (TargetMol Bioactive Compound Library)
Cell lines
1
Organisms
3
Compound Sets
18
BOC Sciences Bioactive Compounds
fpl-64176-cas-120934-96-5-item-196773
Cayman Chemical Bioactives
20122
Concise Guide to Pharmacology 2017/18
2518
Concise Guide to Pharmacology 2019/20
2518
Concise Guide to Pharmacology 2021/22
2518
Concise Guide to Pharmacology 2023/24
2518
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DMB8U4F
DrugMatrix
Guide to Pharmacology
2518
LOPAC library
MedChem Express Bioactive Compound Library
HY-103307
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T22788
Tocris Bioactive Compound Library
1403
Tocriscreen Plus
1403
Tocriscreen Total
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
347.15
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
3
cLogP
4.24
TPSA
59.16
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
L-type
Target
L-type calcium channel
CACNA1C, CACNA1S
Calcium Channel
Primary Target
CaV1.x Channels (L-type)
MOA
Activator
Calcium channel stimulator L-type
L-Type Calcium Channel Activators
"Calcium channel stimulator L-type
L-Type Calcium Channel Activators"
calcium channel activator
Member status
member
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Metabolism
Source data