General
Preferred name
GUVACINE HYDROCHLORIDE
Synonyms
Guvacine (hydrochloride) ()
P&D ID
PD015115
CAS
6027-91-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 ¦ÌM (human GAT-1), 39 ¦ÌM (rat GAT-1), 58 ¦ÌM (rat GAT-2), 119 ¦ÌM (human GAT-3), 378 ¦ÌM (rat GAT-3), and 1870 ¦ÌM (human BGT-3).
PRICE 29
DESCRIPTION Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 ??M)
DESCRIPTION Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter. (Enamine Bioactive Compounds)
DESCRIPTION GABA uptake inhibitor (LOPAC library)
DESCRIPTION Guvacine hydrochloride is a specific GABA uptake inhibitor (IC50 = 14, 58, 119 and 1870 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1, respectively). Guvacine may be beneficial for the treatment of neuropsychiatric disorders. (BOC Sciences Bioactive Compounds)
DESCRIPTION Specific GABA uptake inhibitor (Tocriscreen Total)
DESCRIPTION Guvacine hydrochloride is an inhibits of GABA uptake (IC50 : 10 μM) (TargetMol Bioactive Compound Library)
Compound Sets
8
BOC Sciences Bioactive Compounds
guvacine-hydrochloride-cas-6027-91-4-item-29773
Cayman Chemical Bioactives
23361
Enamine Bioactive Compounds
EBC-12569
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
HY-100809
TargetMol Bioactive Compound Library
T7557
Tocriscreen Total
External IDs
11
Properties
(calculated by RDKit )
Molecular Weight
163.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
0
cLogP
0.41
TPSA
49.33
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Target
GABA
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Neuroscience
Source data