General
Preferred name
L-655,708
Synonyms
L-655708, NCGC00025115-02 ()
L-655708 ()
P&D ID
PD015080
CAS
130477-52-0
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective ligand for the benzodiazepine site of GABA-A receptors which contain the alpha5 subunit (LOPAC library)
DESCRIPTION Selective for alpha5-containing GABAA receptors (Tocriscreen Plus)
DESCRIPTION Benzodiazepine antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Selective for α5-containing GABAA receptors (Tocriscreen Total)
DESCRIPTION L-655,708, an inverse agonist of α5 subunit involved in GABAA receptor, has been found to exhibit cognitive performance improvement in biological studies. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
14
Axon Medchem Screening Library
3390
BOC Sciences Bioactive Compounds
l-655-708-cas-130477-52-0-item-163435
Cayman Chemical Bioactives
30322
Drug Repurposing Hub
DrugMAP
DM4CDIB
EU-OPENSCREEN Bioactive Compound Library
EOS101758
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL52030
MedChem Express Bioactive Compound Library
HY-14426
ReFrame library
Tocris Bioactive Compound Library
1327
Tocriscreen Plus
1327
Tocriscreen Total
ZINC Tool Compounds
ZINC000002584032
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
341.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
2.35
TPSA
73.66
Fraction CSP3
0.39
Chiral centers
1.0
Largest ring
7.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Ion Channels
Selectivity
GABA-A
Primary Target
GABAA Receptors
MOA
Benzodiazepine
GABA receptor inverse agonist
Target
GABRA1, GABRA2, GABRA3, GABRA5, GABRG2
GABAA-a5 agonist
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Solubility
10 mM in DMSO
Source data